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Uses of Intravenous Immunoglobulin (IVIG) Therapy
IVIG is used to treat a number of autoimmune disorders, idiopathic
diseases (disease of unknown cause), and infections.
FDA Approved Uses
The US Food and Drug Administration has approved the use of IVIG for the following 7 conditions:
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Immune Thrombocytopenic Purpura (ITP)
- Primary Immunodeficiency states
- Secondary Immunodeficiency in Chronic Lymphocytic Leukemia
- Pediatric human immunodeficiency virus (HIV) infection
- Kawasaki disease
- Prevention of Graft vs. Host disease in an adult bone marrow transplant recipient
The first four conditions account for 70% of IVIG use.[1]
Other Uses
Given the broad action of IVIG, it can also be used to treat a
variety of other conditions, in which controlled trials establishing
the safety and efficacy are still needed. Some of these off-label
uses are:
- Neurological diseases: Guillain - Barré
syndrome, CIDP, myasthenia gravis, Lambert-Eaton myasthenic syndrome, multifocal motor neuropathy and
multiple sclerosis.
- Dermatological diseases: Autoimmune blistering dermatoses, dermatomyositis, pemphigus, pemphigoid.
- Rheumatological diseases: Rheumatoid
arthritis (adult and juvenile), systemic lupus erythematosus, systemic vasculitides, dermatomyositis,
polymyositis, inclusion-body myositis and Wegeners granulomatosis.
- Hematological diseases: Aplastic anemia, pure
red cell aplasia, diamond-blackfan anemia,
autoimmune hemolytic anemia, hemolytic disease
of the newborn, acquired factor VIII inhibitors,
acquired von Willebrand disease, immunemediated neutropenia and neonatal alloimmune/
autoimmune thrombocytopenia.
- Infectious diseases: Acquired infectious disease
that could be deleterious in low birth weight baby (ie, less than 1500 g), solid organ transplantation,
extensive burns and HIV infection.
- Respiratory disease: Asthma.
- Miscellaneous: Acute idiopathic
dysautonomia, acute disseminated encephalomyelitis, hemophagocytic syndrome,
multiple myeloma and POEMS syndrome, recurrent pregnancy loss.
Further Readings
To find detailed information about uses of IVIG in treatment of a particular disease, please click on the link of the disease you are interested in:
Effectiveness of IVIG in Treatment of
CIDP >>>
Effectiveness of IVIG in Treatment of
GBS >>>
Effectiveness of IVIG in Treatment of
Alzheimer's Disease >>>
Effectiveness of IVIG in Treatment of
Dermatology >>>
Effectiveness of IVIG Therapy in
Treatment of Dermatomyositis >>>
Effectiveness of IVIG Therapy in
Treatment of Pemphigus >>>
Effectiveness of IVIG in Treatment of
Primary Immunodeficiency >>>
Effectiveness of IVIG in Treatment of Prevention of Recurrent Pregnancy Loss>>>
References
1.Darabi, K., O. Abdel-Wahab, and W.H. Dzik, Current usage of intravenous immune globulin and the rationale behind it: the Massachusetts General Hospital data and a review of the literature. Transfusion, 2006. 46(5): p. 741-53. Medline.
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